Endocrine Abstracts

A 69 years old female with cervical radiotherapy 25 years ago for an unknown condition, known with multinodular goitre and hyperthyroidism for 6 years, presented with a 6 months history of enlarged right supraclavicular mass, local pain with difficulty in mobilization of the right arm and weight loss. She also reported progressive bilateral exophtalmia especially on the right side, no dysphagia, hoarseness or dyspnoea. Thyroid hormone levels were normal on antithyroid drugs an...

Primary aldosteronism (PA) is the most common form of secondary hypertension. In the majority of cases it is caused by unilateral aldosterone producing adenoma (APA) or by bilateral adrenal hyperplasia. Although the majority of cases of PA are sporadic, the disease may occur in the context of familial hyperaldosteronism where it is associated with specific germline mutations. Recent advances in genome technology have improved our understanding on the genetic basis of PA, allow...

Introduction and aims: Numerous studies in recent years have confirmed the existence of a link between endothelial dysfunction and vascular diseases, and lifestyle factors such as obesity, sedentary lifestyle and smoking.Methods: We examined 108 patients with obesity (90 women and 18 men, mean age 54.62±0.4 years). All patients underwent clinical and laboratory examination. Vasomotor endothelial function was evaluated by reactive hyperemia using ult...

Pituitary dysfunctions, reported as ‘hypopituitarism’ or ‘hypophysitis’, are relatively common side-effects induced by monoclonal antibodies (mAbs) inhibiting specific immune checkpoints. In particular, hypophysitis represents a distinctive side effect of CTLA4-blocking antibodies and is a new form of autoimmune pituitary disease.In initial trials, the incidence of hypophysitis induced by anti-CTLA4-mAbs (ipilimumab and tremelimumab) ...

Introduction: Embryonal antitumour modulator of Mkrtchyan (EATM) reveals a hypoglycemic effect in streptozotocin-induced diabetes in rats. The aim of the work was to determine the influence of EATM on the process of releasing of Nox of erythrocyte membranes (EM) and serum of patients with diabetes type 1 and 2.Materials and methods: The study included 12 patients with type 1 diabetes, 12 patients with type 2 diabetes and 12 healthy volunteers. Isolation ...

Introduction and aims: Obesity is associated with increased single-nephron glomerular filtration rate, which may increase the risk of chronic kidney disease (CKD). Several biopsy studies showed the association between obesity and higher prevalence of CKD features, including segmental glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arterial sclerosis. Another approach is to study intra-renal hemodynamics by ultrasound, where renal parenchymal damage in obesity m...

Background: Primary hyperparathyroidism during pregnancy is rare, and may present with symptoms non-specific to hypercalcaemia.Case: A 35 years old 12/40 weeks pregnant lady presented to accident and emergency department with 6 weeks history of nausea and vomiting. On admission she felt anxious with ongoing nausea and numbness all over the body. She was a mother 2-year-old with no significant past medical history. Her medication on admission were; folic ...

Introduction: The N-formyl peptide receptor (FPR) family of G-protein-coupled receptors, originally identified to recognise N-formylated bacterial peptides, has in more recent times been shown to bind annexin-1 (ANXA1). ANXA1 is a signalling molecule well demonstrated to mediate two key glucocorticoid effects in the anterior pituitary: inhibition of ACTH release from corticotrophs and regulation of cell proliferation. Whilst previous RT-PCR studies have detec...

Thirty five patients (33 women, 2 men) age 26–67 who had calcifications in the thyroid gland in a result of ultrasound examination, the levels of parathyroid hormone, vitamin D and microliters (Ca++, Mg++ and Phosphorus) have been determined as well. The level of 25(OH) in the studied groups were significantly reduced and was within the following range; 14 ± 7 ng/ml. Twenty five patients had hyperparathyroidism, which indicated ...

Sex steroid hormone-induced variations of vascular smooth muscle cells (VSMCs) migration are critical in determining the sex/gender-related differences in male and female pathophysiology of cardiovascular system. Although several substances present in the environment, defined endocrine disruptors (EDs), could interfere with androgen and estrogen effects, the sex/gender-related susceptibility of VSMC motility to these substances is completely unknown. Here, naringenin (Nar) and...